Current arguments to increase shareholder power in the large public U.S. corporation need to take account of the well-established historical practice of extensive delegation by shareholders of business decision-making and agenda-control to management and the board, what might be characterized as an absolute delegation rule. This practice sharply limits the power of shareholders to put either business or governance proposals to the shareholders for dispositive resolution. The paper, originally published in 1991 but newly relevant, argues that the rule is based (...) on potential pathologies in shareholder voting rather than the inherent information asymmetry between shareholders and managers. Rational shareholders who know of this asymmetry (and know that others know) would simply vote against most shareholder proposals. But shareholder voting gives rise to potential cycling problems, as shifting shareholder majorities vie for preferred policies, and potential opportunism, as shareholders engage in side deals with management and other shareholders to extract rents in corporate decision-making. Since shareholding patterns are in part a response to control rights, deviations from the absolute delegation rule will predictably lead to greater block ownership, for defensive and offensive reasons. These concerns need to be addressed in arguments for the expansion of shareholder power. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

In New Philosophy for New Media, Mark Hansen defines the image in digital art in terms that go beyond the merely visual. Arguing that the "digital image" encompasses the entire process by which information is made perceivable, he places the body in a privileged position -- as the agent that filters information in order to create images. By doing so, he counters prevailing notions of technological transcendence and argues for the indispensability of the human in the digital era.Hansen examines new (...) media art and theory in light of Henri Bergson's argument that affection and memory render perception impure -- that we select only those images precisely relevant to our singular form of embodiment. Hansen updates this argument for the digital age, arguing that we filter the information we receive to create images rather than simply receiving images as preexisting technical forms. This framing function yields what Hansen calls the "digital image." He argues that this new "embodied" status of the frame corresponds directly to the digital revolution: a digitized image is not a fixed representation of reality, but is defined by its complete flexibility and accessibility. It is not just that the interactivity of new media turns viewers into users; the image itself has become the body's process of perceiving it.To illustrate his account of how the body filters information in order to create images, Hansen focuses on new media artists who follow a "Bergsonist vocation"; through concrete engagement with the work of artists like Jeffrey Shaw, Douglas Gordon, and Bill Viola, Hansen explores the contemporary aesthetic investment in the affective, bodily basis of vision. The book includes over 70 illustrations from the works of these and many other new media artists. (shrink)

Eliminativists sometimes invoke evolutionary debunking arguments against ordinary object beliefs, either to help them establish object skepticism or to soften the appeal of commonsense ontology. I argue that object debunkers face a self-defeat problem: their conclusion undermines the scientific support for one of their premises, because evolutionary biology depends on our object beliefs. Using work on reductionism and multiple realizability from the philosophy of science, I argue that it will not suffice for an eliminativist debunker to simply appeal to some (...) object-free surrogate theory of evolution that results from converting any scientific proposition about some object K into a proposition about simples arranged K-wise. In the process, I examine some hazards peculiar to eliminative reductions of scientific theories, and propose a trilemma for eliminativists who attempt to recoup generality for ontologically sparse reducing theories by appealing to pluralities of simples arranged K-wise. The paper is intended to define and develop the object debunker’s self-defeat problem for further study, and to clarify some of the ways sparse and abundant ontologies interact with scientific theory. (shrink)

Argument invention is a method that can be used to help an arguer find arguments that could be used to prove a claim he needs to defend. The aim of this paper is to show how argumentation systems recently developed in artificial intelligence can be applied to the task of argument invention. One such system called Carneades is featured. Carneades can be used to analyze arguments, evaluate arguments, to make an argument diagram, and to construct arguments from a database. Using (...) some simple examples, the paper explains how Carneades works as a system of argument invention. (shrink)

Argument invention is a method that can be used to help an arguer find arguments that could be used to prove a claim he needs to defend. The aim of this paper is to show how argumentation systems recently developed in artificial intelligence can be applied to the task of argument invention. One such system called Carneades is featured. Carneades can be used to analyze arguments, evaluate arguments, to make an argument diagram, and to construct arguments from a database. Using (...) some simple examples, the paper explains how Carneades works as a system of argument invention. (shrink)

The field of psychology, including cognitive science, is vexed by a crisis of confidence. Although the causes and solutions are varied, we focus here on a common logical problem in inference. The default mode of inference is significance testing, which has a free lunch property where researchers need not make detailed assumptions about the alternative to test the null hypothesis. We present the argument that there is no free lunch; that is, valid testing requires that researchers test the null against (...) a well-specified alternative. We show how this requirement follows from the basic tenets of conventional and Bayesian probability. Moreover, we show in both the conventional and Bayesian framework that not specifying the alternative may lead to rejections of the null hypothesis with scant evidence. We review both frequentist and Bayesian approaches to specifying alternatives, and we show how such specifications improve inference. The field of cognitive science will benefit because consideration of reasonable alternatives will undoubtedly sharpen the intellectual underpinnings of research. (shrink)

The Monty Hall Problem (MHP), a process of two-stage decision making, was presented in atypical form via a custom software game. Differing from the normal three-box MHP, the game added one additional box on-screen for each game—culminating on game 23 with 25 on-screen boxes to initially choose from. A total of 108 participants played 23 games (trials) in one of four conditions; (1) “Vanish” condition—all non-winning boxes totally removed from the screen; (2) “Empty” condition—all non-winning boxes remain on-screen, but with (...) an “empty” label on them; (3) “Steroids” condition—all non-winning boxes removed from the screen, with initially chosen box becoming 25% larger; (4) “Steroids2” condition—all non-winning boxes removed from the screen, box not currently chosen becomes 25% larger. Results indicate second-stage on-screen presence of boxes influences switching; with their absence having the opposite effect. Size manipulation appears to elicit demand characteristics resulting in indeterminate influence. (shrink)

Cognitive scientist Donald Hoffman and others have recently advanced an evolutionary debunking argument aimed at our perceptual beliefs in ordinary objects, based on the Interface Theory of Perception. In contrast with most recent criticisms of Interface Theory, which have targeted its characterizations of perception and veridicality, I raise a broad dialectical problem for Hoffman’s debunking argument. I show that the argument is self-defeating, and that responding to this problem by appealing to Universal Darwinism leads to a fatal dilemma for the (...) view. (shrink)

This essay assesses the way that issues relating to freedom of speech and public and private forms of dissent have and have not changed in the People’s Republic of China in recent decades. It looks at the way China’s unusual trajectory suggests that Nathan Sharansky’s famous “town square test,” which is often used to divide countries along a single axis (with “free” nations on one side, “fear” nations on the other) is problematic. The need to take regional variations within China (...) into account is one theme that is stresses. (shrink)

Some metabolic pathways are nearly ubiquitous among organisms: the genes encoding the enzymes for such pathways must therefore be ancient and essential. De novo pyrimidine biosynthesis is an example of one such metabolic pathway. In animals a single protein called CADAbbreviations: CAD, trifunctional protein catalyzing the first three steps of de novo pyrimidine biosynthesis in higher eukaryotes; CPS, carbamyl phosphate synthetase domain; CPSase, carbamyl phosphate synthetase activity; ATC, aspartate transcarbamylase domain; ATCase, aspartate transcarbamylase activity; DHO, dihydroorotase domain; DHOase, dihydroorotase activity; (...) GLN, glutaminase subdomain or subunit of carbamyl phosphate synthetase, GL Nase, glutaminase activity; SYN, synthetase subdomain or subunit of carbamyl phosphate synthetase; SYNase, synthetase activity. carries the first three steps of this pathway. The same three enzymes in prokaryotes are associated with separate proteins. The CAD gene appears to have evolved through a process of gene duplication and DNA rearrangement, leading to an in‐frame gene fusion encoding a chimeric protein. A driving force for the creation of eukaryotic genes encoding multienzymatic proteins such as CAD may be the advantage of coordinate expression of enzymes catalyzing steps in a biosynthetic pathway. The analogous structure in bacteria is the operon. Differences in the translational mechanisms of eukaryotes and prokaryotes may have dictated the different strategies used by organisms to evolve coordinately regulated genes. (shrink)

This article examines the way in which selfhood is constructed in direct-to-consumer advertisements for antidepressant medications. The sample consists of advertisements that appeared in nine popular magazines between 1997 and 2005, television commercials that ran between 2003 and 2005, and online promotional Web sites. The analysis is divided into three sections. First, it is argued that the ads rely on metaphors of communication, information exchange, and plenitude to construct a relationship between biology and selfhood. Second, in offering the choice for (...) antidepressant treatment, the ads grant individuals a new capacity for the exercise of personal agency. Third, the author describes antidepressants as pills that perform a narrative “magic.” In contrast to religious and psychoanalytic narratives that required individuals to incorporate disavowed elements of their selves into an ongoing life narrative, antidepressants are medications that allow individuals to put aside, or jump over, inexplicable and painful moments in their life. (shrink)

Students in 1989 were at pains to distinguish their actions from those taken by students in the Cultural Revolution. Yet there were important similarities. In the present paper, we identify influence on the Democracy Movement from the Cultural Revolution through (1) the expansion and/or widespread familiarization of repertories of collective action available to Chinese activists; (2) precedents for collective action that may have lowered the barriers to action for some while raising them for others; (3) the participation of people at (...) different stages of their lives in both movements; (4) the transformation of the significance of the ideas of democracy and political authority wrought by the Cultural Revolution for many Chinese; (5) the impact of the Cultural Revolution on Chinese intellectuals; (6) the material consequences of the Cultural Revolution which contributed to China's position in the post-Mao era and the specific issues reform and protest sought to confront; (7) the discourse of corruption which provided the 1989 movement with its strongest links between students and ordinary citizens, and which was accentuated in the Cultural Revolution; (8) the affirmation of the value of ordinary life by which students in the 1980s, encouraged by the `literature of the wounded', rebelled against the Puritanism and denigration of `unauthorized' personal relationships that had been characteristic of the Cultural Revolution; (9) the role of the Cultural Revolution as a cautionary tale, shaping the movement itself, inhibiting some older intellectuals from participating, and determining much of how the government viewed and responded to the Democracy Movement; and (10) the embeddedness in different ways of both Cultural Revolution and 1989 protests in an international context. (shrink)

In their article in the September-October 2010 issue of IRB: Ethics & Human Research, Chris Kaposy and Françoise Baylis argue that the contraception policy of the University of Nebraska Medical Center’s institutional review board fails to meet an ethically ideal standard in establishing the criteria investigators should follow when including women of childbearing potential in clinical research. In this response, we argue that the UNMC IRB’s policy is evidence-based and pragmatically oriented and that it therefore better safeguards women’s autonomy than (...) an ideal policy could. We also offer some of our experiences with the policy since it was implemented six years ago. (shrink)

Making recognition decisions often requires us to reference the contents of working memory, the information available for ongoing cognitive processing. As such, understanding how recognition decisions are made when based on the contents of working memory is of critical importance. In this work we examine whether recognition decisions based on the contents of visual working memory follow a continuous decision process of graded information about the correct choice or a discrete decision process reflecting only knowing and guessing. We find a (...) clear pattern in favor of a continuous latent strength model of visual working memory–based decision making, supporting the notion that visual recognition decision processes are impacted by the degree of matching between the contents of working memory and the choices given. Relation to relevant findings and the implications for human information processing more generally are discussed. (shrink)

The process-dissociation procedure was used to estimate the influence of spatial and form-based processing in the Simon task. Subjects made manual responses to the direction of arrows . The results provide evidence that the form and spatial location of a single stimulus can have functionally independent effects on performance. They also indicate the existence of two kinds of automaticity—an associative component that reflects prior S-R mappings and a nonassociative component that reflects the correspondence between stimulus and response codes.

Concussions in professional sports have received increased attention, which is partly attributable to evidence that found concussion incidence rates were much higher than previously thought. Further to this, professional hockey players articulated how their concussion symptoms affected their professional careers, interpersonal relationships, and qualities of life. Researchers are beginning to associate multiple/repeated concussions with Chronic Traumatic Encephalopathy, a structural brain injury that is characterized by tau protein deposits in distinct areas of the brain. Taken together, concussions impact many people in (...) the sporting community from current and former professional athletes and their families to medical and health professionals and researchers. In light of the growing awareness and sensitivity towards concussions, the purpose of this paper is to provide recommendations that are designed to improve player safety in professional hockey and address the ethical issues surrounding these suggestions. (shrink)

The Reeh-Schlieder theorem asserts the vacuum and certain other states to be spacelike superentangled relative to local fields. This motivates an inquiry into the physical status of various concepts of localization. It is argued that a covariant generalization of Newton-Wigner localization is a physically illuminating concept. When analyzed in terms of nonlocally covariant quantum fields, creating and annihilating quanta in Newton-Wigner localized states, the vacuum is seen to not possess the spacelike superentanglement that the Reeh-Schlieder theorem displays relative to local (...) fields, and to be locally empty as well as globally empty. Newton-Wigner localization is then shown to be physically interpretable in terms of a covariant generalization of the center of energy, the two localizations being identical if the system has no internal angular momentum. Finally, some of the counterintuitive features of Newton-Wigner localization are shown to have close analogues in classical special relativity. (shrink)

We consider an extension of signaling games to the case of prediction, where one agent perceives the current state of the world and sends a signal. The second agent perceives this signal, and makes a prediction about the next state of the world. We suggest that such games may be the basis of a model for the evolution of successful theorizing about the world.

In this paper I will present conceptions of state reduction and particle and/or system localization which render these subjects fully compatible with the general requirements of a relativistic, i.e. Lorentz invariant, quantum theory. The approach consists of a systematic generalization of the concepts of initial data assignment at definite times, initiation and completion of measurements at definite times, and dynamical evolution as time dependence, to the concepts of initial data assignment on arbitrary space-like hyperplanes, initiation and completion of measurements on (...) arbitrary space-like hyperplanes, and dynamical evolution as space-like hyperplane dependence, respectively. I also briefly discuss the superluminal propagation which emerges from the localization study and the manner in which causal anomalies are nevertheless avoided. (shrink)

Over the past 25 years, no religious institution in America has done more to explore the link between the environment and spirituality than the Cathedral of St. John the Divine. Now, for the first time, a selection of the finest of the Cathedral's ecological sermons appears in a single volume.

This is the first of two papers responding to ‘recent’ commentary on various aspects of hyperplane dependence by several authors. In this paper I focus on the issues of the relations of HD to state reduction and unitary evolution. The authors who’s comments I address here are Maudlin and Myrvold. In the second paper of this set I focus on HD dynamical variables and localizable properties and measurements and address comments of de Koning, Halvorson, Clifton and Wallace. Each paper ends (...) with some reflections on the implications of HD for the ontology of Minkowski space-time. To set the stage for my responses, I begin this paper with some general position statements designed to correct what seem to be widespread and erroneous construals of some of my views. Two central points are argued for in this first paper. First, dynamical evolution occurs not only within foliations of Minkowski space-time. Rather the transition from the physical state of affairs on any one hyperplane to any other, whether the hyperplanes intersect or are parallel, is always an instance of dynamical evolution between them, generated by some active combination of boost-like transformations and/or time-like translations and/or state reductions and ‘reconstructions’. This point gives rise to a generalized conception of a history of dynamical evolution, allowing for the use of parameterized families of hyperplanes that multiply cover some portions of space-time. Nevertheless, and this is the second central point, for any two generalized histories, H and H’, the quantum states for a system on all the hyperplanes of H from the asymptotic past up to some hyperplane, h, determine the quantum states for the system on all the hyperplanes of H’ from the asymptotic past up to any hyperplane, h’, such that h’ lies to the past of all those state reduction regions that lie to the future of all hyperplanes of H that are ‘earlier’ than h. Consideration of these results should defuse concerns that have been voiced about the coherence and consistency of HD. A position closely related to the second point has already been argued for by Myrvold. (shrink)

This is the second of two papers responding (somewhat belatedly) to ‘recent’ commentary on various aspects of hyperplane dependence (HD) by several authors. In this paper I focus on the issues of the general need for HD dynamical variables, the identification of physically meaningful localizable properties, the basis vectors representing such properties and the relationship between the concepts of ‘localizable within’ and ‘measureable within’. The authors responded to here are de Koning, Halvorson, Clifton and Wallace. In the first paper of (...) this set (Fleming 2003b) I focused on the issues of the relations of HD to state reduction and unitary evolution and addressed comments of Maudlin and Myrvold. The central conclusion argued for in this second paper (§§ 5, 7) is the non-existence of strictly localizable objects or measurement processes and the consequent undermining of the principle of universal microcausality. This contrasts with the existence of strictly localizable properties and results in the consequent priority of the concept of ‘localizable within’ over ‘measureable within’. The paper opens with discussions of the need for and status of HD dynamical variables which are responses to anonymous queries. (shrink)

Through the explicit introduction of hyperplane dependence as a form of relativistic dynamical evolution, we construct a manifestly covariant description of a single positive energy particle interacting with any one of a large class of “moving” external potentials. In1+1 dimensions, the simplified mathematics allows us to display a number of general properties of solutions to the equations of motion for evolution on hyperplanes.

This paper is concerned with the interpretation of velocity eigenstates for unstable quantons, their relationship to space-like momentum eigenstates for such quantons and the explanation of Shirokov’s contracting lifetimes for such velocity eigenstates. It is an elaboration of a portion of the authors earlier study.

An inequality in quantum mechanics, which does not appear to be well known, is derived by elementary means and shown to be quite useful. The inequality applies to 'all' operators and 'all' pairs of quantum states, including mixed states. It generalizes the rule of the orthogonality of eigenvectors for distinct eigenvalues and is shown to imply all the Robertson generalized uncertainty relations. It severely constrains the difference between probabilities obtained from 'close' quantum states and the different responses they can have (...) to unitary transformations. Thus, it is dubbed a master inequality. With appropriate definitions the inequality also holds throughout general probability theory and appears not to be well known there either. That classical inequality is obtained here in an appendix. The quantum inequality can be obtained from the classical version but a more direct quantum approach is employed here. A similar but weaker classical inequality has been reported by Uffink and van Lith. (shrink)

The long established but infrequently discussed dependence of Lorentz boost generators on the presence and nature of interactions is reviewed in this tutorial note. The last third of the note presents a discussion of the covariant transformation and evolution equations for the non-conserved partial generators of the inhomogeneous Lorentz group for interacting subsystems.

This article presents empirical evidence to address how some visitors build relationships with a wildland place over time. Insights are drawn from qualitative interviews of recreation visitors to the backcountry at Rocky Mountain National Park in Colorado. The article describes relationship to place as the active construction and accumulation of place meanings. The analysis is organized around three themes that describe how people develop relationships to place: time and experience accrued in place, social and physical interactions in and with the (...) setting, and an active reflective process of regulating sense of identity to affirm commitment to place. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Triumph Of SisyphusJeffrey GordonThe gods had condemned Sisyphus to ceaselessly rolling a rock to the top of the mountain, whence the stone would fall back of its own weight. They had thought with some reason that there is no more dreadful punishment than futile and hopeless labor.1The words are, of course, Albert Camus's. They were first published in 1942. Since then, this voice—at once lyrical and austere, personal (...) and oracular—and the ancient image he calls up in these lines have become permanent parts of our postmodern consciousness. Like all the images that capture and create the character of our age, Sisyphus is always there for each of us. In the intimate space of our imagination, we can turn to him at will, and with only the slightest effort, we will find him as before—solitary, weather beaten, resigned, without illusion. I want to make that effort now, not to disturb Sisyphus in his labors, nor to uproot him, surely, but to try to be precise about a matter which is, perhaps, fatally elusive of precision, to try to make explicit the significance of this figure whose implicit significance has haunted us now for over half a century. Let us turn to Sisyphus, then, as we might turn, one aimless afternoon, to some old photographs of a person close to us, perhaps even of ourselves, in the hope that we might find in them something we had missed, some expression or gesture that inadvertently reveals the essence of a life.But we must be silent now, for the figure is emerging. There is the hill, and it is morning, a slight chill in the soundless air. The landscape here is treeless, the land covered only with broken rock and scattered brush. A wide path of sterile earth has been cut in the thick brush of [End Page 183] the hill. And there, at the base of the hill, the rock—grey, mottled with holes, enormous. Slow, laborious breathing is audible. The rough hand comes into view, the flesh thick, sun-burnt, heavily veined. It finds a jut on the rock to grip. And now the weather-worn clothes, the thick trunk and powerful back. And here at last the face of Sisyphus—our own face, of course, or the face of one of our own personae, the eyes squinting against the sun, hair disheveled. He takes his hand from the rock and brings it to his side. Perhaps he is not quite ready yet, perhaps he needs a moment longer of rest. He stands motionless, eyes turning up. What is he gazing at? The summit of the hill, every square inch of which he has seen a million times before? What could he hope to discover there? Is it the cloudless sky that has his attention? Is he noting the progress of the sun? Does he seek in reflection on its course some inspiration for the renewal of his labor? He continues to stare without expression. We can afford to leave him for a moment.The legend abounds in perplexities, or at least this is true of that retelling of the myth that has made it so important to us. Camus calls Sisyphus "the absurd hero." This is, then, the best that we can hope to be, for our lives, too, according to Camus, are absurd. But why should we believe this? Surely it is ludicrously question-begging to conduct an imaginative exercise in which we strip a life of all that could possibly make it worthwhile, then appeal to this figment of ours as proof of the futility of human existence.If we are tempted to see in Sisyphus's eternal rock-rolling a revelation of the emptiness of our own labors, we should be easily dissuaded from this when we consider what little alteration is required to transform this myth from the perfect image of meaninglessness to a perfectly serviceable conception of a meaningful life.2 All we need is to introduce some point, some minimal, common, everyday point to his labors, such as any one of our lives abounds in, and the transformation is accomplished. Assume, then, that Sisyphus rolls... (shrink)

Calling the quantity; 2ΔAΔB/|<[A, B]>|, with non-zero denominator, the uncertainty product ratio or UPR for the pair of observables, (A, B), it is shown that any non-zero correlation coefficient between two observables raises, above unity, the lower bound of the UPR for each member of an infinite collection of pairs of incompatible observables. Conversely, any UPR is subject to lower bounds above unity determined by each of an infinite collection of correlation coefficients. This result generalizes the well known Schroedinger strengthening (...) of the Robertson uncertainty relations (with the former expressed in terms of the correlation coefficient rather than the anticommutator) where the UPR and the correlation coefficient both involve the same pair of observables. Two, independent, derivations of the result are presented to clarify its’ origins and some examples of its’ use are examined. (shrink)

A recent argument by Pitowsky (1991), leading to the relativity (as opposed to objectivity) of quantum predictions, is refuted. The refutation proceeds by taking into account the hyperplane dependence of the quantum predictions emerging from the three mutually space-like separated measurements, performed on an entangled state of three spin 1/2 particles, that Pitowsky considers. From this hyperplane dependence one finds that the logical step of conjoining the predictions from distinct measurements is ineffective since those predictions apply either, locally, to sets (...) of points with an intersection that is inaccessible to the particles, or globally, to sets of hyperplanes with an intersection that is empty. We also see how explicit reference to the hyperplane dependence of the predictions gives covariant expression to the invariant content of the predictions, which are thereby shown to be objective. (shrink)